Is Venous Thromboembolism a Risk Factor for Arterial Events?
SUMMARY AND COMMENT
Myocardial infarction and stroke were observed in patients with unprovoked pulmonary embolisms.
Reviewing:
Klok FA et al., Blood 2009 Aug 20; 114:1484
Improving Follow-Up for ED Patients Who Lack Access to Primary Care
SUMMARY AND COMMENT
Scheduling follow-up appointments before ED discharge improved the rate of follow-up among low-income patients without access to primary care, but, most patients did not show up for their appointments.
Reviewing:
Chan TC et al., Ann Emerg Med 2009 Aug; 54:279
Predicting Mortality in Patients with Severe Acute Pancreatitis
SUMMARY AND COMMENT
A simple new scoring system proved both sensitive and specific for mortality.
CME
Reviewing:
Singh VK et al., Am J Gastroenterol 2009 Apr; 104:966
Physician Recommendations to Limit Life Support — What Do Surrogates Want?
SUMMARY AND COMMENT
And when are physicians obligated to offer a recommendation?
Interview
Reviewing:
White DB et al., Am J Respir Crit Care Med 2009 Aug 15; 180:320
Good News and Bad News About 2009 H1N1 Influenza ("Swine Flu")
SUMMARY AND COMMENT
Only a minority of stored serum samples in the U.S. contained antibodies against H1N1, but a new vaccine easily elicited them.
Reviewing:
Hancock K et al., N Engl J Med 2009 Sep 10
Clark TW et al., N Engl J Med 2009 Sep 10
Greenberg ME et al., N Engl J Med 2009 Sep 10
H1N1 Update: Oseltamivir Resistance and Antiviral Use
NEWS IN CONTEXT
The CDC reports oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection in two children who received prophylaxis and provides revised recommendations for antiviral use during the 2009 flu season.
CME
Reviewing:
Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2009 Sep 11; 58:969
Centers for Disease Control and Prevention (CDC)., 2009 Sep 8
Which Pneumococcal Vaccine for Adults with COPD?
SUMMARY AND COMMENT
In a small study, serologic responses were generally better with the 7-valent protein-conjugate vaccine than with the currently approved 23-valent polysaccharide vaccine.
Reviewing:
Dransfield MT et al., Am J Respir Crit Care Med 2009 Sep 15; 180:499
Preexisting Immunity to the 2009 H1N1 Virus
SUMMARY AND COMMENT
Very few individuals younger than 30 have protective levels of cross-reactive neutralizing antibodies against this virus.
Reviewing:
Hancock K et al., N Engl J Med 2009 Sep 10
New Hope for HIV Vaccine Development
SUMMARY AND COMMENT
Using a novel technique, researchers identified antibodies that neutralize a broad array of HIV strains.
Reviewing:
Walker LM et al., Science 2009 Sep 3
2009 H1N1 Vaccine: Will One Dose Be Enough?
SUMMARY AND COMMENT
A single 15-µg dose of 2009 H1N1 vaccine, without an adjuvant, produced strong immune responses in 97% of healthy adults.
Reviewing:
Greenberg ME et al., N Engl J Med 2009 Sep 10
Neuzil KM., N Engl J Med 2009 Sep 10