Tiotropium Attenuates Symptoms in Moderate COPD but Does Not Slow Progression
SUMMARY AND COMMENT
Tiotropium can be as effective for patients with early-stage COPD as it is for patients with more-severe disease.
Reviewing:
Decramer M et al., Lancet 2009 Oct 3; 374:1171
Davies L and Calverley PMA., Lancet 2009 Oct 3; 374:1129
Depression Is Bad for Your Heart
SUMMARY AND COMMENT
And attaining remission significantly improves mortality risk in patients with acute coronary syndromes.
Reviewing:
Glassman AH et al., Arch Gen Psychiatry 2009 Sep; 66:1022
Compress the Chest: Better CPR Improves Survival from Out-of-Hospital Cardiac Arrest
SUMMARY AND COMMENT
Implementation of the 2005 AHA CPR guidelines that focus on uninterrupted chest compressions nearly doubled the odds of survival among patients with out-of-hospital cardiac arrest.
Reviewing:
Sayre MR et al., Prehosp Emerg Care 2009 Oct-Dec; 13:469
Getting Stroke Patients to the Hospital Sooner
SUMMARY AND COMMENT
Surprisingly, only women responded to an intervention aimed at recognizing stroke symptoms and calling emergency medical services.
Reviewing:
Müller-Nordhorn J et al., Arch Intern Med 2009 Sep 14; 169:1484
A Glimmer of Hope for HIV Vaccines
SUMMARY AND COMMENT
October 22, 2009
Frances H. Priddy, MD, MPH, and Carlos del Rio, MD
HIV/AIDS Clinical Care
A large trial has shown that a vaccine can protect against HIV acquisition. The task now is to figure out how to build on this initial success.
Reviewing:
Rerks-Ngarm S et al., N Engl J Med 2009 Oct 20
Dolin R., N Engl J Med 2009 Oct 20
Effect of Weight Loss on Obstructive Sleep Apnea in People with Type 2 Diabetes
SUMMARY AND COMMENT
Losing 25 lbs resulted in significantly fewer OSA events in obese patients.
Reviewing:
Foster GD et al., Arch Intern Med 2009 Sep 28; 169:1619
Aldosterone Antagonists and Heart Failure
SUMMARY AND COMMENT
Potholes remain in the road toward adoption of evidence-based guideline recommendations.
Reviewing:
Albert NM et al., JAMA 2009 Oct 21; 302:1658
Surgical Masks or N95 Respirators for the Flu?
SUMMARY AND COMMENT
In a randomized trial, surgical masks and N95 respirators provided healthcare workers with comparable protection against influenza.
Reviewing:
Loeb M et al., JAMA 2009 Oct 1
High Perioperative Oxygen Fraction and SSIs, Revisited
SUMMARY AND COMMENT
In a large, randomized, clinical trial, administration of 80% oxygen had no effect on surgical-site infections or pulmonary complications.
Reviewing:
Meyhoff CS et al., JAMA 2009 Oct 14; 302:1543
Immune Response from Bronchoalveolar Lavage Mononuclear Cells Diagnoses Active TB
SUMMARY AND COMMENT
ELISpot performed on bronchoalveolar mononuclear cells had a sensitivity of 91% and a specificity of 79% in diagnosing active disease.
Reviewing:
Jafari C et al., Am J Respir Crit Care Med 2009 Oct 1; 180:666